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Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets

Direct liraglutide treatment of isolated aged rat cardiomyocytes restored the depolarized mitochondrial membrane potential, reduced reactive oxygen and nitrogen species (ROS and RNS), and normalized cytosolic Na + levels, despite the Na + channel currents remaining unaffected by aging

Mechanistically, UA enhances mitochondrial -oxidation and potentially activating skeletal muscle adenosine 5-monophosphate-activated protein kinase (AMPK) signaling and upregulating mitochondrial respiratory chain complex activity to exert ergogenic effects

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